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“Our goal is to grasp female reproductive growing old, and why fertility promptly declines commencing during the mid-30s,” states Satoshi Namekawa, a professor of Microbiology and Molecular Genetics, in whose lab Munakata is effective.
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Munakata and Namekawa will compare mice with standard and mutated variations with the chromatin remodeler. Since the mice expand and experienced, they may notice whether the existence or absence of this protein triggers dissimilarities while in the arrangement of DNA spools in the animals’ oocytes. And they'll check irrespective of whether this, in turn, alters the sample of gene expression as time passes.
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Namekawa believes that in human oocytes, modifications in these styles could disrupt the sensitive choreography of genes becoming turned on and off at the appropriate moments — leaving them unprepared for fertilization or progress into healthy embryos. Variations in chromatin composition as an oocyte ages might also influence the way that chromosomes segregate throughout cell division.
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